Tamara Powell, Jesse Powell's sister, has reported that Jesse Powell has died peacefully at his home in Los Angeles.
The R&B artist Mr Powell, originally from Indiana, was best known for his song You. The song was originally released in 1996 and re-released two years later.
Ms Powell revealed the news to fans that the singer had died at his home in LA at the age of 51, sharing a tribute as she broke the news.
She wrote: 'It is with a heavy heart that we announce the death of our beloved son, brother, and uncle Jesse Powell.
Jesse's fans were always supportive throughout his musical career and he loved them for it.
The cause of death for Mr Powell, older brother of singers Trina and Tamara Powell, is unknown.
Ms Powell later added a clip of her brother singing, and said to her followers: "That voice! Aside from being one of the best R&B male vocalists out there, you were the best big brother ever."